Depression is a serious medical condition that can take so much out of you. I feel like I have to wind myself up just to get out of bed. Then, well, I have to keep winding myself up to deal with the sadness, the loss of interest, the trouble concentrating, the lack of energy. If depression is taking so much out of you, ask your doctor about Pristique. Pristique is a prescription medicine proven to treat depression. Pristique is thought to work by affecting the levels of two chemicals in the brain, serotonin and norepinephrine. Tell your doctor right away if your depression worsens or you have unusable changes in mood, behavior, or thoughts of suicide. Antidepressants can increase suicidal thoughts and behaviors in children, teens, and young adults. Pristique is not approved for children under 18. Do not take Pristique with MAOIs. Taking Pristique with NSAID pain relievers, aspirin, or blood thinners may increase bleeding risk. Tell your doctor about all your medications, including those for migraine, to avoid a potentially life-threatening condition. Pristique may cause or worsen high blood pressure, high cholesterol, or glaucoma. Tell your doctor if you have heart disease or before you reduce or stop taking Pristique. Side effects may include nausea, dizziness, and sweating. For me, Pristique is a key in helping to treat my depression. Ask your doctor about Pristique.